Following heatmaps present the correlation between distances computed from multiple sequence alignment (MSA) versus pairwise local alignment. Distance computation from MSA is explained in the previous post at http://salsafungiphy.blogspot.com/2013/06/pairwise-distance-calculation.html. Distances computed from pairwise local alignment follows the usual recipe of using Smith-Waterman with -16/-4 gap penalties and EDNAFULL scoring matrix for alignment followed by percent identity based distance computation. A similar study was done with previous data as well (see http://salsafungiphy.blogspot.com/2012/10/pairwise-distances-from-multiple.html).
No comments:
Post a Comment